This is possibly old news for many, but i almost made the following mistake and wanted to make others aware of it.  As you reach the second quest hub with Saeradan, you’ll be presented a quest option from Andref the Quartermaster,

lotroclient 2010-09-21 19-04-27-29

If you take the option to “Feed the Company” you’ll miss out on some valuable repeatable quest reputation with the Algraig, which is by far the harder reputation to grind.  In addition you’ll miss out on a repeatable gold token quest which is the more valuable barter token needed for ports, horses, etc.  The quest dialog does indicate the choice but not so much on the long term impact so it is easy to miss.

If you’re not concerned with reputation this isn’t a big deal, but if it weren’t for this forum thread I would’ve made my reputation grind much steeper.