I was doing Medusa today on Atlantic and for some strange reason Enemy of One was not doing any extra damage. Her bar was changing colors but the damage was no different than without it cast. I was using a Repond Slayer Hatchet with 45DI and a total of 45 DI on my suit with 120 Tactics (I swap between 70 Anatomy and 70 Resisting Spells depending on Spellcasting abilities of the mobs) and spamming Lightning Strike with Perfection and I was only doing 40-45 damage on normal hits and 110-130 on Criticals and AI's. I thought it was just a fluke the first time but confirmed it after doing 3 Medusa's in total back to back. Normally it takes me around 10-12 minutes but each of these took about 25 minutes each. This was my first time doing Medusa in a few weeks and have never had a problem like this with her before.