here is my solution for target nearest enemy (or any kind of target): I found this nice program Mouse Wheel Control that works for every apps/games for a cheap price. With this program you associate a key to the mouse wheel. With this you can also put macros on the mouse wheel (like target/attack last)! This program will work on classic client too EDIT: Here is a free alternative: X-Mouse Button. This allow you to change the function of every mouse buttons and bind it to a key.