I'll just state some of my background with gaming. I started playing UO around the time AoS was announced but not yet released. I got into World of Warcraft soon after it was released, and have been playing it competitively since then (about 6 years). I've been doing arenas as a mage in that game since the concept was introduced, and have been forced to change keybinds/macros like crazy to keep up. I am now getting back into UO, and have been trying to implement everything I learned from WoW into my UO playstyle. Something I learned from playing WoW, is that you can never have too many keybinds, and that your most timing-oriented spells/abilities should all be as close to each other with as little movement across the keyboard as possible. Since this game doesn't use WASD for movement, this makes it all the easier. I use a Logitech MX518 mouse, but any mouse with at least 1 thumb button should suffice. I remapped my first thumb button (mouse4) to act as SHIFT key, and my second thumb button (mouse5) to act as the CTRL key. This essentially triples the amount of hotkeys I can use on my keyboard. I use a Windows program called 'X-Mouse Button Control v1.52' for this. For simplicity sake, all you really need is 1 thumb button on the side of your mouse. The QWE, ASD, and ZXC keys (all positioned closely for better access) will be what you bind spells and abilities to, as well as SHIFT+Q,W,E,A,S,D,Z,X,C for a second set of spells in the same spot on the keyboard. This eliminates having to move your left hand across the keyboard in a heated situation. Not sure how useful this keybinding strategy works for melee, but as a longtime caster, I think this is very close to an optimal setup. If anyone else does something similar, I'd love to know how.